Return Slope (normalized slope of the drug response curve) for an experiment of a pSet by taking its concentration and viability as input.

Return Slope (normalized slope of the drug response curve) for an experiment of a pSet by taking its concentration and viability as input.

Usage

computeSlope(concentration, viability, trunc = TRUE, verbose = TRUE)

Arguments

concentration

numeric A concentration range that the AUC should be computed for that range. Concentration range by default considered as not logarithmic scaled. Converted to numeric by function if necessary.

viability

numeric Viablities corresponding to the concentration range passed as first parameter. The range of viablity values by definition should be between 0 and 100. But the viabalities greater than 100 and lower than 0 are also accepted.

trunc

logical(1) A flag that identify if the viabality values should be truncated to be in the range of (0,100)

verbose

logical(1) If 'TRUE' the function will retrun warnings and other infomrative messages.

Value

Returns the normalized linear slope of the drug response curve

Examples

dose <- c(0.0025,0.008,0.025,0.08,0.25,0.8,2.53,8)
viability <- c(108.67,111,102.16,100.27,90,87,74,57)
computeSlope(dose, viability)
#> [1] 0.14