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Loewe Additive Combination Index (CI)

Source: R/computeSynergy.R
loeweCI.Rd

Computes the Loewe additive combination index (CI) from its definition \( CI = \frac{x_1}{f_1^{-1}(E)} + \frac{x_2}{f_2^{-1}(E)} \)

Usage

loeweCI(
  viability,
  treatment1dose,
  HS_1,
  E_inf_1,
  EC50_1,
  treatment2dose,
  HS_2,
  E_inf_2,
  EC50_2,
  is_pct = FALSE
)

Arguments

viability

numeric is a vector whose entries are the viability values in the range [0, 1].

treatment1dose

numeric a vector of concentrations for treatment 1

HS_1

numeric Hill coefficient of treatment 1

E_inf_1

numeric the maximum attainable effect of treatment 1.

EC50_1

numeric relative EC50 of treatment 1.

treatment2dose

numeric a vector of concentrations for treatment 2

HS_2

numeric Hill coefficient of treatment 2

E_inf_2

numeric the maximum attainable effect of treatment 2.

EC50_2

numeric relative EC50 of treatment 2.

is_pct

logical whether both the input viabiliy and E_inf are given in percentage ([0, 100]) rather than decimal ([0, 1]). Default FALSE.

Value

CI under Loewe additive definition

Examples

if (FALSE) {
tre |>
    endoaggregate(
        assay="combo_viability",
        Loewe = PharmacoGx::computeLoewe(
            treatment1dose = treatment1dose,
            treatment2dose = treatment2dose,
            HS_1 = HS_1,
            HS_2 = HS_2,
            E_inf_1 = E_inf_1,
            E_inf_2 = E_inf_2,
            EC50_1 = EC50_1,
            EC50_2 = EC50_2
        ),
        by = assayKeys(tre, "combo_viability")
    ) -> tre
}