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A data.frame containing a subset of cell lines and driver mutations from the Genomics of Drug Sensitivity in Cancer (GDSC) dataset.

Source: R/CBWWorkshop2024_module1_data.R
GDSC_drivers.Rd

This is a subset of the GDSC driver mutations dataset from Iorio et al. 2016 containing cancer driver mutation status for a random selection of cell lines.

Usage

data(GDSC_drivers)

Format

data.frame object

References

  1. Yang, W., Soares, J., Greninger, P., Edelman, E. J., Lightfoot, H., Forbes, S., Bindal, N., Beare, D., Smith, J. A., Thompson, I. R., Ramaswamy, S., & Futreal, P. A. (2013). Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Research, 41(D1), D955–D961. https://doi.org/10.1093/nar/gks1111

  2. Iorio, F., Knijnenburg, T. A., Vis, D. J., Bignell, G. R., Menden, M. P., Schubert, M., Aben, N., Gonçalves, E., Barthorpe, S., Lightfoot, H., Cokelaer, T., Greninger, P., van Dyk, E., Chang, H., de Silva, H., Heyn, H., Deng, X., Egan, R. K., Liu, Q., Mironenko, T., … Garnett, M. J. (2016). A Landscape of Pharmacogenomic Interactions in Cancer. Cell, 166(3), 740–754. https://doi.org/10.1016/j.cell.2016.06.017

  3. Garnett, M. J., Edelman, E. J., Heidorn, S. J., Greenman, C. D., Dastur, A., Lau, K. W., Greninger, P., Thompson, I. R., Luo, X., Soares, J., Liu, Q., Iorio, F., Surdez, D., Chen, L., Milano, R. J., Bignell, G. R., Tam, A. T., Davies, H., Stevenson, J. A., … Benes, C. H. (2012). Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature, 483(7391), 570–575. https://doi.org/10.1038/nature11005